DETAILS, FICTION AND อ่านเพิ่มเติม

The interactions of p62 as well as the UPS, autophagy and ubiquitinated proteins. On UPS inhibition, p62 is upregulated and phosphorylated on S405 and S409, which can aid the degradation of ubiquitinated cargoes by means of autophagy. p62 synthesis is induced by an increase in Nrf2 adhering to UPS deficiency. The amplified p62 competes with Nrf2 fo